Progress Report

$$$ = complete

$$ = in progress

$ = preliminary stage

Geometric Models Team

• Work on pre-processing software
  • $$ Re-organize existing code so it is readable and workable
  • $$$ Set up color table so that gleason grades, prostate components are uniquely and uniformly indentified for all samples
  • $$$ Ensure that software handles as much as possible before manual editing stage (Automated cleanup, filling of areas)
  • $$ Create utilities to convert model data into whatever format is necessary for visualization or analysis
• Work on 3-d visualization of geometric models
  • $$$ Search for public domain software which may be applicable: Vis5d 4.1 (http://www.ssec.wisc.edu/~billh/vis5d.html) VolVis 2.0 (http://www.cs.sunysb.edu/~volvis/vislab.html) PolyPaint+ (http://polypaint.colorado.edu:4444/home.html#toc) VolPack (http://www-graphics.stanford.edu/software/volpack/)
  • $$$ Check out commercial software which may be useful: Matlab, IDL (on carbon), 3DVIEWNIX (http://www.mipg.upenn.edu/~Vnews/3dviewnix_ftp.html#demo)
• $$ Provide tumor data for other teams.

Biopsy Team

• $$ understand current 3-d biospy code.
• $$ write our own biopsy simulation using tumor data
• $$ write our own biopsy simulation using random ellipsoids
• (not a goal) understand SCRSCB method and assess it using 3-d biospy code.
• $$$ learn some geometric probability/tomography and decide if it is relevant or offers an alternative to simulations.
• $ propose and evaluate other biopsy protocols
• determine whether a biopsy method can distinguish between "insignificant" and "significant" tumors.

Morphometric Models Team

• $ mathematical characterization of size and shape of tumors
• $$ investigate "point of origin" questions
• $$ develop secondary data base that holds both tumor variables and patient variables.
• $$ design presentation of data in secondary data base.
• $$ design analysis and correlation methods for variables in secondary data base.
• $$ investigate issue of "insignificant" versus "significant" tumors,

CA Team

• $$ learn enough to design transition rules for CA growth model.
• $$ actual development of a CA growth model

Database